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Glossary Liquid chromatography / Term

Extracolumn effects

The total band broadening effects of all parts of the chromatographic system outside of the column itself. Extracolumn effects must be minimized to maintain the efficiency of a column. Sources of band broadening can include the injector design, injection volume, connecting tubing, endfittings, frits, detector cell volume, and internal detector tubing. The variances of all of these contributions are additive.

Permanent link Extracolumn effects - Creation date 2022-03-05


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